You can up-tier the various uniques that drop to make them Destruction (Hell) difficulty-proof, reroll items inexpensively, enhance them with alchemy, disenchant them to get their residue, remake them from scratch, craft them with shrines and then bless them for end-game epicness.
However, this makes it too easy to get up to speed it's really a newbie feature that should have been left out. This Gift Box can quickly be farmed over and over again to get an array of class-relevant uniques. Drops are much more generous, frequent and useful these include jewels, runes, gems and magic and rare items.Unlike the preceeding Median XL 2012 v005 (the version I play), Ultimative added a 100% chance 'Gift Box' drop from Griswold that rewards you with unique items relevant to your class. You also level-up much faster, hitting second level on your tenth slay.
Besides, this added difficulty is mostly offset by your increased base rate of movement (+FRW), increased base rate of attack and casting (+IAS/+FCR) and deeper mana and health pools with faster regen rates.